褪黑激素(melatonin)有助乳癌治療 Melatonin and Breast Cancer

褪黑激素(melatonin)有助乳癌治療 褪黑激素是一種幫助誘導良好睡眠的荷爾蒙，晚間光綫減弱後，人體會分泌褪黑激素令人產生睡意。 除此之外，多年來褪黑激素一直應用於治療乳腺癌相關症狀。 最新研究揭示了褪黑激素具有抗癌特性，實驗室研究表明，它可以減緩乳腺癌的生長和擴散。 目前已有足夠臨床證據顯示，在常規乳腺癌療法中添加褪黑激素可以提高治療效果並減少副作用的產生。 研究表明，褪黑激素有助預防導致乳腺癌的好幾種危險因素，包括某些環境因素、肥胖和晚間長期暴露於強光等誘因。 Melatonin and Breast Cancer Melatonin, a hormone known for inducing a good night’s sleep, has been used for many years in the treatment of symptoms associated with breast cancer. New research reveals melatonin’s anticancer properties, and lab studies show that it can slow the growth and spread of breast cancer. The addition of melatonin to conventional breast cancer therapies has been shown to boost effectiveness and reduce side effects. Studies show that melatonin can help protect against breast cancer risk factors, including certain environmental exposures, obesity, and being exposed to light at night. References 1, Subramanian A, Kothari L. Suppressive effect by melatonin on different phases of 9,10-dimethyl-1,2-benzanthracene (DMBA)-induced rat mammary gland carcinogenesis. Anticancer Drugs. 1991;2(3):297-303. 2, Cos S, Sanchez-Barcelo EJ. Melatonin, experimental basis for a possible application in breast cancer prevention and treatment. Histol Histopathol. 2000;15(2):637-47. 3, Cos S, Sanchez-Barcelo EJ. Melatonin and mammary pathological growth. Front Neuroendocrinol. 2000;21(2):133-70. 4, Hill SM, Blask DE. Effects of the pineal hormone melatonin on the proliferation and morphological characteristics of human breast cancer cells (MCF-7) in culture. Cancer Res. 1988;48(21):6121-6. 5, Sanchez-Barcelo EJ, Cos S, Fernandez R, et al. Melatonin and mammary cancer: a short review. Endocr Relat Cancer. 2003;10(2):153-9. 6, Hill SM, Belancio VP, Dauchy RT, et al. Melatonin: an inhibitor of breast cancer. Endocr Relat Cancer. 2015;22(3):R183-204. 7, Lissoni P, Barni S, Mandala M, et al. Decreased toxicity and increased efficacy of cancer chemotherapy using the pineal hormone melatonin in metastatic solid tumour patients with poor clinical status. Eur J Cancer. 1999;35(12):1688-92. 8, Onseng K, Johns NP, Khuayjarernpanishk T, et al. Beneficial Effects of Adjuvant Melatonin in Minimizing Oral Mucositis Complications in Head and Neck Cancer Patients Receiving Concurrent Chemoradiation. J Altern Complement Med. 2017;23(12):957-63. 9, Wilson ST, Blask DE, Lemus-Wilson AM. Melatonin augments the sensitivity of MCF-7 human breast cancer cells to tamoxifen in vitro. J Clin Endocrinol Metab. 1992;75(2):669-70.